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Your search keyword '"Yakuwa, Naho"' showing total 44 results
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44 results on '"Yakuwa, Naho"'

2. Effects of maternal modafinil treatment on fetal development and neonatal growth parameters — a multicenter case series of the European Network of Teratology Information Services (ENITS)

Author

Onken, Marlies, primary, Lohse, Lukas, additional, Coulm, Bénédicte, additional, Beghin, Delphine, additional, Richardson, Jonathan L., additional, Bermejo‐Sánchez, Eva, additional, Aguilera, Cristina, additional, Bosch, Montserrat, additional, Cassina, Matteo, additional, Chouchana, Laurent, additional, De Santis, Marco, additional, Duman, Mine Kadioglu, additional, Gören, M. Zafer, additional, Johnson, Diana, additional, Bera, Annie Pierre Jonville, additional, Kaplan, Yusuf C., additional, Kennedy, Debra, additional, Kwok, Susan, additional, Lacroix, Isabelle, additional, Lepelley, Marion, additional, Pistelli, Alessandra, additional, Schaefer, Christof, additional, Te Winkel, Bernke, additional, Uysal, Nusret, additional, Winterfeld, Ursula, additional, Yakuwa, Naho, additional, Diav‐Citrin, Orna, additional, Vial, Thierry, additional, and Dathe, Katarina, additional

Published
2023
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6. Transfer of Zolpidem to Cord Blood and Breast Milk: A Case Series Evaluating Zolpidem Serum Levels and Outcomes in Birth and Suckling Infants

Author

Saito, Jumpei, primary, Tachibana, Yoshiyuki, additional, Kawasaki, Hiroyo, additional, Tamon, Hiroki, additional, Ishii, Mariko, additional, Wada, Yuka Sano, additional, Oho, Motoko, additional, Yakuwa, Naho, additional, Suzuki, Tomo, additional, Sago, Haruhiko, additional, Yamatani, Akimasa, additional, and Murashima, Atsuko, additional

Published
2022
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11. The safety of pranlukast and montelukast during the first trimester of pregnancy: A prospective, two‐centered cohort study in Japan

Author

Hatakeyama, Shiro, primary, Goto, Mikako, additional, Yamamoto, Ayaka, additional, Ogura, Jiro, additional, Watanabe, Norikazu, additional, Tsutsumi, Seiji, additional, Yakuwa, Naho, additional, Yamane, Ritsuko, additional, Nagase, Satoru, additional, Takahashi, Kunihiko, additional, Kosaki, Rika, additional, Murashima, Atsuko, additional, and Yamaguchi, Hiroaki, additional

Published
2022
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13. Presence of Hypnotics in the Cord Blood and Breast Milk, with No Adverse Effects in the Infant: A Case Report

Author

Saito, Jumpei, primary, Tachibana, Yoshiyuki, additional, Sano Wada, Yuka, additional, Kawasaki, Hiroyo, additional, Miura, Yoriko, additional, Oho, Motoko, additional, Aoyagi, Kaori, additional, Yakuwa, Naho, additional, Suzuki, Tomo, additional, Yamatani, Akimasa, additional, Sago, Haruhiko, additional, and Murashima, Atsuko, additional

Published
2022
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19. Investigation on the accumulation of background and pregnancy outcome information on cases consulted by the Japan Drug Information Institute in Pregnancy.

Author

Yakuwa, Naho, Murashima, Atsuko, and Miyazaki, Seiko

Subjects
PREGNANCY outcomes, PREGNANCY, MEDICAL personnel, PREGNANT women, CHILD development
Abstract

Since pregnant women are excluded from clinical trials, it is essential to accumulate post‐marketing information to evaluate the effects on the fetus of medication use during pregnancy. The Japan Drug Information Institute in Pregnancy (JDIIP) was established at the National Center for Child Health and Development as a Ministry of Health, Labour, and Welfare project to provide patients with information and conduct follow‐up surveys. In this study, we investigated the status of the accumulation of JDIIP consultation cases to identify issues for enhancing clinical information appropriate for use during pregnancy and to examine how information should be collected and provided. In addition, the status of descriptions of Japanese package inserts, which are representative of those used by healthcare professionals as a source of information, was confirmed for medications used by JDIIP consultation cases. The characteristics of the JDIIP consultation cases information were that the contents that needed to be adjusted when evaluating the effects on the fetus of medication use during pregnancy were obtained. In addition, the follow‐up rate was 83.1%. However, although the number of consultation facilities has increased, the number of consultations has not, indicating the need to further increase the number. It was found that there is limited information on epidemiological studies of clinical use in Japanese package inserts. To improve clinical information on the appropriate use of medications during pregnancy, it is necessary to accumulate more information in the future, and it is considered necessary to consider new approaches utilizing the JDIIP system. [ABSTRACT FROM AUTHOR]

Published
2024
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20. Establishment of a measurement system to evaluate breast milk transfer of biological agents using dry filter paper: A multi‐institutional study.

Author

Saito, Jumpei, Yakuwa, Naho, Hosokawa, Yoshihiko, Hamada, Hiromi, Suzuki, Tomo, Sago, Haruhiko, Kaneko, Kayoko, Yamatani, Akimasa, and Murashima, Atsuko

Subjects
BREAST milk, FILTER paper, BREAST milk collection & preservation, DRYING agents, BREASTFEEDING, ENZYME-linked immunosorbent assay, GOLIMUMAB, ABATACEPT
Abstract

Aims: Information on breastfeeding and safety of biologics in infants is lacking due to difficulties in case collection. We evaluated methods for determining the concentration of biologics in breast milk using a dry filter method that can simplify the collection, storage and transport of breast milk. Methods: To generate dried filter paper (DFP) samples, approximately 30 μL of breast milk was placed onto a Whatman 903 card and punched out. After extraction, the supernatant was measured using an enzyme‐linked immunosorbent assay. Three concentrations of each drug were prepared in liquid breast milk (LBM) and DFP samples to determine their stability up to 28 days after storage at 2–8°C or −20°C for LBM and 25 ± 5°C for DFP. LBM and DFP samples were also provided by nursing mothers using biologics during lactation, and drug concentrations in both samples were compared. The agreement between the two measurement methods was confirmed by Bland–Altman analysis. Results: Breast milk was provided by 12 mothers who used biologics (tocilizumab, abatacept, etanercept, golimumab, sarilumab and belimumab). The coefficients of variation for within‐run and between‐run precision for the six drugs were within 15% for both LBM and DFP, and accuracy was within 90%–110% of the quality controls. After 28 days, concentrations remained at more than 90%. The difference between the values obtained by each method was within the acceptable range of error (−12.1 to +16.6 ng/mL). Conclusions: A method for determining the concentration of biologics using DFP is expected to help improve pharmacotherapy for lactating women. [ABSTRACT FROM AUTHOR]

Published
2024
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24. Omalizumab concentrations in pregnancy and lactation: A case study

Author

Saito, Jumpei, primary, Yakuwa, Naho, additional, Sandaiji, Noriko, additional, Uno, Chiaki, additional, Yagishita, Sachiko, additional, Suzuki, Tomo, additional, Ozawa, Katsusuke, additional, Kamura, Shunsuke, additional, Yamatani, Akimasa, additional, Wada, Seiji, additional, Sago, Haruhiko, additional, and Murashima, Atsuko, additional

Published
2020
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25. Tocilizumab drug levels during pregnancy and lactation: A woman who discontinued tocilizumab therapy until the end of the first trimester and resumed it after birth

Author

Saito, Jumpei, primary, Yakuwa, Naho, additional, Kaneko, Kayoko, additional, Goto, Mikako, additional, Kawasaki, Hiroyo, additional, Hamamachi, Yurie, additional, Suzuki, Tomo, additional, Sago, Haruhiko, additional, Yamatani, Akimasa, additional, and Murashima, Atsuko, additional

Published
2020
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29. Safety of Amlodipine in Early Pregnancy

Author

Mito, Asako, primary, Murashima, Atsuko, additional, Wada, Yoshinao, additional, Miyasato‐Isoda, Mai, additional, Kamiya, Chizuko A., additional, Waguri, Masako, additional, Yoshimatsu, Jun, additional, Yakuwa, Naho, additional, Watanabe, Omi, additional, Suzuki, Tomo, additional, Arata, Naoko, additional, Mikami, Masashi, additional, and Ito, Shinya, additional

Published
2019
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36. Pravastatin concentrations in maternal serum, umbilical cord serum, breast milk and neonatal serum during pregnancy and lactation: A case study.

Author

Saito, Jumpei, Kaneko, Kayoko, Abe, Sawako, Yakuwa, Naho, Kawasaki, Hiroyo, Suzuki, Tomo, Yamatani, Akimasa, Sago, Haruhiko, and Murashima, Atsuko

Subjects
PREECLAMPSIA prevention, PRAVASTATIN, LACTATION, ANTIPHOSPHOLIPID syndrome, BREAST milk, LIQUID chromatography, UMBILICAL cord, HEALTH outcome assessment, CORD blood, MASS spectrometry, PREGNANCY
Abstract

What is known and objective: Statins are associated with improved pregnancy outcomes in patients with preeclamptic antiphospholipid syndrome (APS) and intrauterine foetal death. Several studies showed that statins are not teratogenic. However, data characterizing placental transfer and excretion of pravastatin into breast milk are limited. Case summary: We experienced two patients diagnosed with APS received 10 mg of pravastatin from the first trimester until delivery to prevent pre‐eclampsia. Pravastatin concentrations in maternal serum, infant serum and cord blood were evaluated. The estimated maternal‐foetal transfer ratios of pravastatin in the two patients were 25.5% and 23.8% respectively. Pravastatin was eliminated from neonatal serum within 2 days. Both infants developed normally with no drug‐related adverse effects. Pravastatin was not detected in either patient's breast milk at 3 days after the last dose. What is new and conclusion: The infants delivered from the mothers who were treated with pravastatin during pregnancy had no apparent adverse effects. [ABSTRACT FROM AUTHOR]

Published
2022
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38. Brotizolam During Pregnancy and Lactation: Brotizolam Levels in Maternal Serum, Cord Blood, Breast Milk, and Neonatal Serum.

Author

Jumpei Saito, Mariko Ishii, Yoriko Miura, Naho Yakuwa, Hiroyo Kawasaki, Tomo Suzuki, Akimasa Yamatani, Haruhiko Sago, Yoshiyuki Tachibana, Atsuko Murashima, Saito, Jumpei, Ishii, Mariko, Miura, Yoriko, Yakuwa, Naho, Kawasaki, Hiroyo, Suzuki, Tomo, Yamatani, Akimasa, Sago, Haruhiko, Tachibana, Yoshiyuki, and Murashima, Atsuko

Published
2021
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40. Tocilizumab drug levels during pregnancy and lactation: A woman who discontinued tocilizumab therapy until the end of the first trimester and resumed it after birth.

Author

Saito, Jumpei, Yakuwa, Naho, Kaneko, Kayoko, Goto, Mikako, Kawasaki, Hiroyo, Hamamachi, Yurie, Suzuki, Tomo, Sago, Haruhiko, Yamatani, Akimasa, and Murashima, Atsuko

Subjects
LACTATION, TOCILIZUMAB, BREAST milk, CORD blood, COLOSTRUM, RHEUMATOID arthritis, TERMINATION of treatment, PREGNANCY
Abstract

The demand for tocilizumab is increasing in women who wish to bear children and who have active rheumatoid arthritis. Described here is a woman with rheumatoid arthritis who discontinued her tocilizumab therapy at the end of the first trimester and resumed it after delivery and where tocilizumab levels in maternal serum, infant serum, and the breast milk were measured. Tocilizumab was not detected in maternal serum just before delivery, or in umbilical cord blood or infant serum after birth. Tocilizumab levels in colostrum after intravenous injection were 0.57% of those in serum. Tocilizumab treatment in the first trimester was not associated with a significant drug level in the fetus at delivery and no fetal complications were noted. [ABSTRACT FROM AUTHOR]

Published
2021
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43. Safety of Amlodipine in Early Pregnancy.

Author

Asako Mito, Atsuko Murashima, Yoshinao Wada, Mai Miyasato-Isoda, Kamiya, Chizuko A., Masako Waguri, Jun Yoshimatsu, Naho Yakuwa, Omi Watanabe, Tomo Suzuki, Naoko Arata, Masashi Mikami, Shinya Ito, Mito, Asako, Murashima, Atsuko, Wada, Yoshinao, Miyasato-Isoda, Mai, Waguri, Masako, Yoshimatsu, Jun, and Yakuwa, Naho

Published
2019
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